Transgender persons are found in almost every society; these people were present in Medina state and had been found in Arab cities and societies even before Islam. In Arab societies, they were treated as slaves, and it was their only status at that time in those societies. Comparative research has been done in this article on how different societies, civilizations and cultures of the world consider transgender persons as the curse of God. During the period of the Holy Prophet (PBUH), Transgender was given the title "Guardians of Harem", and they used to guard the harems (the place where women and children reside) of the Muslim elites. These persons enjoy the rights of male or female and are bound to obey the directions and commands, which are for a male Muslim and female Muslim. This is a medical disability, just like any other disability and nothing else. In many other societies, civilizations and religions of the world, transgender persons have been deprived of their true status and have been humiliated.